The primary aim of this study was to prepare a buccoadhesive tablet of nimodipine by kneading technology, using optimized concentration of polymer to give maximum retention effect with good release profile. Nimodipine is a 1,4-dihydropyridine calcium channel blocker mainly used for prevention of cerebral vasospasm and resultant ischemia. It is having a low oral bioavailability and undergoes hepatic first pass metabolism. Solubility of nimodipine was enhanced by complexing it with β cyclodexrtin. Prepared tablets were subjected to various physicochemical parametes. In this study, buccoadhesive tablet were prepared which having backing layer of magnesium stearate and ethyl cellulose for support. It was concluded on the basis of buccoadhesive strength and in-vitro release kinetic that optimized formulation, F9 gave the best in-vitro release of drug over a period of 6 hrs.
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